Syntheses of All Regioisomers of Myo-Inositol Bisphosphate

All possible nine regioisomers of myo-inositol bisphosphate were synthesized using various isopropylidene and benzoyl inositol derivatives as intermediates. These intermediates were successfully phosphorylated with diethyl chlorophosphite followed by oxidation. Selective diphosphorylations on severa...

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Bibliographic Details
Published in:Journal of carbohydrate chemistry 1998-04, Vol.17 (3), p.369-384
Main Authors: Chung, Sung-Kee, Chang, Young-Tae, Kwon, Yong-Uk
Format: Article
Language:English
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Summary:All possible nine regioisomers of myo-inositol bisphosphate were synthesized using various isopropylidene and benzoyl inositol derivatives as intermediates. These intermediates were successfully phosphorylated with diethyl chlorophosphite followed by oxidation. Selective diphosphorylations on several IBz 3 intermediates were also examined as possible routes to IP 2S . All of the protecting groups were easily removed in a one-pot procedure to give the sodium salts of the title compounds, IP 2 regioisomers.
ISSN:0732-8303
1532-2327
DOI:10.1080/07328309808002898