New Methods for Multiple Modifications of a Phosphorus Centre. Their Relevance to Nucleotide and Oligonucleotide Analogues Synthesis

Nucleoside phosphoramidates and their analogues with the P‒N bond in bridging positions of the phosphoramidate linkage were prepared by a new method utilizing the corresponding pyridine adducts of metaphosphates. Also, a new procedure was developed for the synthesis of unprotected nucleoside phospho...

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Published in:Nucleosides & nucleotides 1999-06, Vol.18 (6-7), p.1245-1246
Main Authors: Kers, Inger, Cieslak, Jacek, Jankowska, Jadwiga, Kraszewski, Adam, Stawinski, Jacek
Format: Article
Language:English
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Summary:Nucleoside phosphoramidates and their analogues with the P‒N bond in bridging positions of the phosphoramidate linkage were prepared by a new method utilizing the corresponding pyridine adducts of metaphosphates. Also, a new procedure was developed for the synthesis of unprotected nucleoside phosphoromono- and phosphorodithioates.
ISSN:0732-8311
DOI:10.1080/07328319908044678