Structural Requirements at the 15.1-16.1 Position of the Hammerhead Ribozyme

Apart from the A 15.1 *U 16.1 -> I 15.1 *C 16.1 change which reverses the polarity of an important H-bond in the hammerhead structure no other functional group changes at the 15.1 purine residue seem to be compatible with the requirements of efficient catalysis. The I 15.1 and A 15.1 ribozymes ar...

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Bibliographic Details
Published in:Nucleosides & nucleotides 1999-06, Vol.18 (6-7), p.1519-1520
Main Authors: Ludwig, J., Blaschke, M., Dunkel, M., Beijer, B., Ross, K., Sproat, B. S.
Format: Article
Language:English
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Summary:Apart from the A 15.1 *U 16.1 -> I 15.1 *C 16.1 change which reverses the polarity of an important H-bond in the hammerhead structure no other functional group changes at the 15.1 purine residue seem to be compatible with the requirements of efficient catalysis. The I 15.1 and A 15.1 ribozymes are equally suitable for practical applications because there are only minor differences in the acceptance of stabilising residues.
ISSN:0732-8311
DOI:10.1080/07328319908044774