Regression of Left Ventricular Wall Thickness during Ace-Inhibitor Treatment of Essential Hypertension is Associated with an Increase in Insulin Mediated Skeletal Muscle Blood Flow

Left ventricular hypertrophy (LVH) has been associated with insulin resistance, a condition with an impaired insulin-mediated vasodilation in skeletal muscle. ACE-inhibitors have been reported to be superior to most other antihypertensive drugs in inducing a regression of LVH. In a double-blind stud...

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Bibliographic Details
Published in:Blood pressure 1998, Vol.7 (2), p.118-126
Main Authors: ANDERSSON, P.-E, LIND, L, ANDREN, B, HÄNNI, A, RENELAND, R, BERNE, C, LITHELL, H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive agents
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Double-Blind Method
Female
Heart Ventricles - drug effects
Heart Ventricles - pathology
Heart Ventricles - physiopathology
Humans
Hypertension - drug therapy
Hypertension - pathology
Hypertension - physiopathology
Hypoglycemic Agents - pharmacology
Insulin - pharmacology
Insulin Resistance
Male
Medical sciences
MEDICIN
MEDICINE
Middle Aged
Muscle, Skeletal - blood supply
Pharmacology. Drug treatments
Regional Blood Flow - drug effects
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Summary:Left ventricular hypertrophy (LVH) has been associated with insulin resistance, a condition with an impaired insulin-mediated vasodilation in skeletal muscle. ACE-inhibitors have been reported to be superior to most other antihypertensive drugs in inducing a regression of LVH. In a double-blind study with parallel groups, 50 patients with essential hypertension were randomized to treatment with either fosinopril (20 mg o.d.) or atenolol (50 mg o.d.) for 12-16 weeks. Left ventricle wall thickness (LVWT, defined as the sum of interventricular septum and posterior wall), diastolic function (represented by the ratio between the E-wave and the A-wave of mitral blood flow) and femoral artery blood flow (FBF) were evaluated using ultrasonic measurements. FBF was measured at normoinsulinemia and after 2 h of euglycemic hyperinsulinemia. Before treatment, the insulin-induced increase in FBF was inversely related to the LVWT (r
ISSN:0803-7051
1651-1999
1651-1999
DOI:10.1080/080370598437493