MHC-Restricted Presentation of a Single Repeat of MUC1 Mucin

Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1...

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Bibliographic Details
Published in:Immunological investigations 2007-01, Vol.36 (3), p.271-283
Main Authors: Orr, Melody K., Burnside, Janet S., Phillips, Catherine A., Philip, Ramila, Dombrowski, Kenneth E., Wright, Stephen E.
Format: Article
Language:English
Subjects:
Breast Neoplasms - immunology
Breast Neoplasms - therapy
Epitopes - chemistry
Epitopes - genetics
Major Histocompatibility Complex - immunology
MHC restriction
MUC1
Mucin-1 - metabolism
Peptide Fragments - chemistry
Peptide Fragments - genetics
Peptide Fragments - immunology
Peptide Fragments - metabolism
T-Lymphocytes, Cytotoxic - immunology
Tandem Repeat Sequences
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Summary:Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1 peptide presented by allogeneic (MHC-independent) or autologous (MHC-dependent) Epstein-Barr Virus (EBV) immortalized B lymphocytes. The ability to generate greater CTL activity against MUC1-expressing tumor cells by stimulation with autologous versus allogeneic EBV-B supports the hypothesis that presentation of a single repeat of MUC1 peptide is MHC-restricted (MHC-dependent).
ISSN:0882-0139
1532-4311
DOI:10.1080/08820130601187384