CLINICAL IMPROVEMENT OF DIFFUSE LYMPHANGIOMATOSIS WITH PEGYLATED INTERFERON ALFA-2B THERAPY: Case Report and Review of the Literature

Diffuse lymphangiomatosis is a very rare congenital disease, characterized by diffuse or multifocal lymphangioma in the skeletal tissue, spleen, liver, mediastinum, and/or lung. The prognosis is usually poor, especially for children with thoracic lesion, and treatments for the disease are controvers...

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Published in:Pediatric hematology and oncology 2007-01, Vol.24 (7), p.513-524
Main Authors: Ozeki, Michio, Funato, Michinori, Kanda, Kaori, Ito, Masahumi, Teramoto, Takahide, Kaneko, Hideo, Fukao, Toshiyuki, Kondo, Naomi
Format: Article
Language:English
Subjects:
Child
D2-40
diffuse lymphangiomatosis
Humans
Interferon-alpha - administration & dosage
Interferon-alpha - blood
Interferon-alpha - therapeutic use
Lymphangioma - diagnostic imaging
Lymphangioma - drug therapy
Lymphangioma - physiopathology
Male
pegylated interferon alfa-2b
pleural effusion
Polyethylene Glycols
Radiography
Recombinant Proteins
vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
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cited_by cdi_FETCH-LOGICAL-c404t-f621b56869b0e2ee08d1a91b8c6d0d310f8a7eff4d79be42e288e9a8b415b503
cites cdi_FETCH-LOGICAL-c404t-f621b56869b0e2ee08d1a91b8c6d0d310f8a7eff4d79be42e288e9a8b415b503
container_end_page 524
container_issue 7
container_start_page 513
container_title Pediatric hematology and oncology
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creator Ozeki, Michio
Funato, Michinori
Kanda, Kaori
Ito, Masahumi
Teramoto, Takahide
Kaneko, Hideo
Fukao, Toshiyuki
Kondo, Naomi
description Diffuse lymphangiomatosis is a very rare congenital disease, characterized by diffuse or multifocal lymphangioma in the skeletal tissue, spleen, liver, mediastinum, and/or lung. The prognosis is usually poor, especially for children with thoracic lesion, and treatments for the disease are controversial. The authors report a 9-year-old boy with diffuse lymphangiomatosis involving the thorax with pleural effusions, the spleen, and systemic bone. The patient was treated with pegylated interferon alfa-2b, and achieved good clinical and radiological improvement.
doi_str_mv 10.1080/08880010701533603
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ispartof Pediatric hematology and oncology, 2007-01, Vol.24 (7), p.513-524
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Child
D2-40
diffuse lymphangiomatosis
Humans
Interferon-alpha - administration & dosage
Interferon-alpha - blood
Interferon-alpha - therapeutic use
Lymphangioma - diagnostic imaging
Lymphangioma - drug therapy
Lymphangioma - physiopathology
Male
pegylated interferon alfa-2b
pleural effusion
Polyethylene Glycols
Radiography
Recombinant Proteins
vascular endothelial growth factor
Vascular Endothelial Growth Factor A - metabolism
title CLINICAL IMPROVEMENT OF DIFFUSE LYMPHANGIOMATOSIS WITH PEGYLATED INTERFERON ALFA-2B THERAPY: Case Report and Review of the Literature
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