Modulation of the immune system by dying cells and the phosphatidylserine-ligand annexin A5

Apoptotic cell death and the efficient clearance of dying cells are essential mechanisms to control tissue homeostasis and to eliminate potential autoantigens. Numerous alterations on the surfaces of dying cells define a highly characteristic membrane signature and enable an unequivocal distinction...

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Bibliographic Details
Published in:Autoimmunity (Chur, Switzerland) Switzerland), 2007-01, Vol.40 (4), p.254-259
Main Authors: Gaipl, Udo S., Munoz, Luis E., Rödel, Franz, Pausch, Friederike, Frey, Benjamin, Brachvogel, Bent, von der Mark, Klaus, Pöschl, Ernst
Format: Article
Language:English
Subjects:
adjuvant
Animals
Annexin A5
Annexin A5 - immunology
apoptotic cell
Autoantigens - immunology
Autoimmune Diseases - immunology
Autoimmune Diseases - prevention & control
Cell Death
Cell Membrane - immunology
clearance
Humans
Immunization
Ligands
Phagocytosis - immunology
Phosphatidylserines - immunology
Signal Transduction - immunology
tumour vaccine
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Summary:Apoptotic cell death and the efficient clearance of dying cells are essential mechanisms to control tissue homeostasis and to eliminate potential autoantigens. Numerous alterations on the surfaces of dying cells define a highly characteristic membrane signature and enable an unequivocal distinction from vital cells. This way, phagocytosis is initiated and signalling events induced which minimize inflammatory reactions. Therefore, the use of proteins interfering with the clearance process may open up new vistas to improve immunization strategies and may help to understand the mechanisms of autoimmune diseases.
ISSN:0891-6934
1607-842X
DOI:10.1080/08916930701357331