Modulatory effect of hydrogen peroxide on tumoral lymphocytes proliferation

BW 5147 (murine lymphoma cell line). We analyzed the effect of H2O2 in cell proliferation testing nitric oxide and apoptosis. Enzymes involved in the regulation of H2O2 levels as superoxide dismutase (SOD) and peroxidase (PER) were analyzed. H2O2 exerted a biphasic effect. The inhibitory effect of H...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2009-03, Vol.31 (1), p.130-139
Main Authors: Davicino, Roberto, Manuele, María G., Ferraro, Graciela, Micalizzi, Blas, Anesini, Claudia
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Butadienes - pharmacology
Cell Line, Tumor - drug effects
Cell Proliferation - drug effects
Cell Survival - drug effects
Cells, Cultured
ERK pathway
Hydrogen peroxide
Hydrogen Peroxide - metabolism
Hydrogen Peroxide - pharmacology
Imidazoles - pharmacology
Lymph Nodes - cytology
Lymphocytes - cytology
Lymphocytes - drug effects
Lymphocytes - metabolism
lymphoma cell line
Lymphoma, T-Cell - metabolism
Lymphoma, T-Cell - pathology
Male
Mice
Mice, Inbred C3H
Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors
Necrosis - chemically induced
NF-kappa B - metabolism
nitric oxide
Nitric Oxide - metabolism
Nitriles - pharmacology
Nitrites - metabolism
omega-N-Methylarginine - pharmacology
P-38 pathway
p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors
Peroxidase - antagonists & inhibitors
Peroxidase - metabolism
Peroxidase - pharmacology
Protein Kinase Inhibitors - pharmacology
Pyridines - pharmacology
Superoxide Dismutase - antagonists & inhibitors
Superoxide Dismutase - metabolism
Superoxide Dismutase - pharmacology
Superoxides - metabolism
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Summary:BW 5147 (murine lymphoma cell line). We analyzed the effect of H2O2 in cell proliferation testing nitric oxide and apoptosis. Enzymes involved in the regulation of H2O2 levels as superoxide dismutase (SOD) and peroxidase (PER) were analyzed. H2O2 exerted a biphasic effect. The inhibitory effect of H2O2 was related to the activation of the ERK and P38 pathway, NO production and apoptosis. The high proliferation was associated with a low level of H2O2 related to a low SOD and a high PER activities. Drugs capable of producing an increase in H2O2 levels could be used in cancer.
ISSN:0892-3973
1532-2513
DOI:10.1080/08923970802520701