Reduction of saliva-promoted adhesion of Streptococcus mutans MT8148 and dental biofilm development by tragacanth gum and yeast-derived phosphomannan

The aim of this study was to investigate materials which reduce saliva-promoted adhesion of Streptococcus mutans onto enamel surfaces, and their potential in preventing dental biofilm development. The effects of hydroxyapatite (HA) surface pretreatment with hydrophilic polysaccharides on saliva-prom...

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Bibliographic Details
Published in:Biofouling (Chur, Switzerland) Switzerland), 2006-01, Vol.22 (4), p.261-268
Main Authors: Shimotoyodome, A., Kobayashi, H., Nakamura, J., Tokimitsu, I., Hase, T., Inoue, T., Matsukubo, T., Takaesu, Y.
Format: Article
Language:English
Subjects:
Animals
Bacterial Adhesion - drug effects
Biofilms - drug effects
Biofilms - growth & development
Dental biofilm
Dental Plaque - microbiology
Dental Plaque - prevention & control
Hydroxyapatites
Male
Mannans - biosynthesis
Mannans - pharmacology
phosphomannan
Pichia
Pichia - chemistry
Pichia - metabolism
Rats
Saliva - metabolism
Streptococcus mutans
Streptococcus mutans - physiology
Streptococcus mutans adhesion
Tooth - drug effects
Tooth - microbiology
Tragacanth - pharmacology
tragacanth gum
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Summary:The aim of this study was to investigate materials which reduce saliva-promoted adhesion of Streptococcus mutans onto enamel surfaces, and their potential in preventing dental biofilm development. The effects of hydroxyapatite (HA) surface pretreatment with hydrophilic polysaccharides on saliva-promoted S. mutans adhesion in vitro and de novo dental biofilm deposition in vivo were examined. Saliva-promoted adhesion of S. mutans MT8148 was significantly reduced by pretreatment of the HA surface with tragacanth gum (TG) and yeast-derived phosphoglycans. Extracellular phosphomannan (PM) from Pichia capsulata NRRL Y-1842 and TG reduced biofilm development on lower incisors in plaque-susceptible rats when administered via drinking water at concentrations of 0.5% and 0.01%, respectively. The inhibitory effect of TG on de novo dental biofilm formation was also demonstrated when administered via mouthwash in humans. It is concluded that TG and yeast-derived PM have the potential for use as anti-adherent agents and are effective in reducing de novo dental biofilm formation.
ISSN:0892-7014
1029-2454
DOI:10.1080/08927010600902821