Inhibition of Intra-Abdominal Adhesions: A Comparison of Hemaseel APR and Cryoprecipitate Fibrin Glue

Our previous studies demonstrated fibrin glue (FG) prepared from cryoprecipitate (cryo) inhibits intra-abdominal adhesions in rats. A new FG, Hemaseel APR, is Food and Drug Administration (FDA) approved for hemostasis during cardiac surgery and splenic trauma. This study was undertaken to determine...

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Bibliographic Details
Published in:Journal of investigative surgery 2001-01, Vol.14 (4), p.227-233
Main Author: Kelly Meek, Zuri Murrell, Mia Karamatsu, Bruce Stabile, Sameer Amin, Martha Sandoval, Samuel French, Karen Pierre, Christian de Virgilio
Format: Article
Language:English
Subjects:
Abdomen - pathology
Abdomen - surgery
Animals
Colon - pathology
Colon - surgery
Fibrin Glue Adhesion Prevention
Fibrin Tissue Adhesive - pharmacology
Fibrinogen
Male
Omentum - pathology
Omentum - surgery
Rats
Rats, Sprague-Dawley
Surgical Mesh
Tissue Adhesions - prevention & control
Tissue Adhesives - pharmacology
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Summary:Our previous studies demonstrated fibrin glue (FG) prepared from cryoprecipitate (cryo) inhibits intra-abdominal adhesions in rats. A new FG, Hemaseel APR, is Food and Drug Administration (FDA) approved for hemostasis during cardiac surgery and splenic trauma. This study was undertaken to determine if Hemaseel FG prevents intra-abdominal adhesions, and to compare it to cryo FG. Forty-five rats underwent laparotomy. Bilateral peritoneal-muscular defects were created. Polypropylene mesh was sewn into each defect with a running silk suture. The bowel was abraded with gauze. The rats were then randomized to mesh covered with Hemaseel FG, cryo FG, or control. On postoperative day 7, the severity of adhesions were graded by percentage of mesh covered by adhesion (0-100%) and degree of adhesion (0-3). The mean percentage of mesh covered by adhesion was 9% for Hemaseel FG, 43% for cryo FG (p = .005), and 65% for the controls (p < .0001). The mean density adhesion score was 0.5 for Hemaseel FG, 1.2 for cryo FG (p = .04), and 2.1 for the controls (p < .0001). In the Hemaseel FG group, 77% of patches had no adhesions, compared with 37% in the cryo FG group (p = .004) and 13% in the controls (p < .0001). Thus, Hemaseel FG significantly decreases intra-abdominal adhesions, and is more effective than cryo FG.
ISSN:0894-1939
1521-0553
DOI:10.1080/089419301750420269