Comparison of thrombopoiesis during ITP and HIV-ITP and response to intravenous gammaglobulin treatment

Immune thrombocytopenic purpura's diagnosis (ITP) is based on low platelet count and exclusion of clinical conditions rather than a specific diagnostic test. We used the reticulated platelet (RP) assay to study ITP and thrombocytopenia associated with HIV infection (HIV-ITP). Data from 96 ITP a...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2003-08, Vol.14 (5), p.267-276
Main Authors: Gyongyossy-Issa, Maria I. C., Bussel, James B., Carter, Cedric J., Devine, Dana V.
Format: Article
Language:English
Subjects:
Adult
Diagnosis, Differential
HIV Infections - blood
HIV Infections - complications
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Immunoglobulins, Intravenous - therapeutic use
Male
Middle Aged
Platelet Count
Purpura, Thrombocytopenic, Idiopathic - blood
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Retrospective Studies
Thrombocytopenia - blood
Thrombocytopenia - drug therapy
Thrombopoiesis - drug effects
Thrombopoietin - blood
Treatment Outcome
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Summary:Immune thrombocytopenic purpura's diagnosis (ITP) is based on low platelet count and exclusion of clinical conditions rather than a specific diagnostic test. We used the reticulated platelet (RP) assay to study ITP and thrombocytopenia associated with HIV infection (HIV-ITP). Data from 96 ITP and 23 HIV-ITP patients showed low platelet counts (PC) with both high or low %RP suggesting that individuals have different degrees of thrombopoiesis. About 20% of ITP and 46% of HIV-ITP patients had %RP in the 'low' or 'normal' ranges. Grouped by platelet count
ISSN:0953-7104
1369-1635
DOI:10.1080/0953710031000137037