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A combination therapy of calcipotriol cream and PUVA reduces the UVA dose and improves the response of psoriasis vulgaris
BACKGROUND: The addition of calcipotriol ointment to PUVA therapy for psoriasis vulgaris results in a lower total UVA dose and a faster onset of response. The addition of calcipotriol cream to PUVA, however, has not been studied. OBJECTIVE: To investigate whether combining calcipotriol cream with PU...
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| Published in: | The Journal of dermatological treatment 2004-04, Vol.15 (2), p.98-103 |
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| Main Authors: | , , , , , , |
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| container_end_page | 103 |
| container_issue | 2 |
| container_start_page | 98 |
| container_title | The Journal of dermatological treatment |
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| creator | Torras, H Aliaga, A López-Estebaranz, JL Hernández, I Gardeazabal, J Quintanilla, E Mascaró, JM |
| description | BACKGROUND: The addition of calcipotriol ointment to PUVA therapy for psoriasis vulgaris results in a lower total UVA dose and a faster onset of response. The addition of calcipotriol cream to PUVA, however, has not been studied.
OBJECTIVE: To investigate whether combining calcipotriol cream with PUVA therapy has a UVA sparing effect.
METHODS: We performed a randomized, multicentre, vehicle-controlled, double-blind, 12-week comparative study including 120 patients with psoriasis covering 20-50% body surface area. The study consisted of a washout phase followed by a 10-week treatment phase. PUVA therapy three times weekly was added within 1 week after randomization. Efficacy was assessed by the Psoriasis Area and Severity Index (PASI).
RESULTS: At baseline the mean PASI scores were 17.5 and 19.2 in the calcipotriol and vehicle (placebo) groups, respectively. At the end of treatment, the mean PASI scores were 2.65 and 7.03 (p90% was observed in 69% of the patients in the calcipotriol-treated group and in 36.4% of the patients in the vehicle group (p |
| doi_str_mv | 10.1080/09546630410023322 |
| format | article |
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OBJECTIVE: To investigate whether combining calcipotriol cream with PUVA therapy has a UVA sparing effect.
METHODS: We performed a randomized, multicentre, vehicle-controlled, double-blind, 12-week comparative study including 120 patients with psoriasis covering 20-50% body surface area. The study consisted of a washout phase followed by a 10-week treatment phase. PUVA therapy three times weekly was added within 1 week after randomization. Efficacy was assessed by the Psoriasis Area and Severity Index (PASI).
RESULTS: At baseline the mean PASI scores were 17.5 and 19.2 in the calcipotriol and vehicle (placebo) groups, respectively. At the end of treatment, the mean PASI scores were 2.65 and 7.03 (p<0.01), respectively. A reduction in PASI score >90% was observed in 69% of the patients in the calcipotriol-treated group and in 36.4% of the patients in the vehicle group (p<0.01).
CONCLUSION: Calcipotriol cream plus PUVA clearly reduces the cumulative dose of UVA and improves the response of psoriasis vulgaris to PUVA.</description><identifier>ISSN: 0954-6634</identifier><identifier>EISSN: 1471-1753</identifier><identifier>DOI: 10.1080/09546630410023322</identifier><identifier>PMID: 15204160</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>Administration, Cutaneous ; Adult ; Biological and medical sciences ; Calcipotriol ; Calcitriol - administration & dosage ; Calcitriol - analogs & derivatives ; Clinical trial ; Combined Modality Therapy ; Comparative study ; Dermatologic Agents - administration & dosage ; Double-Blind Method ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Photochemotherapy ; Psorias ; Psoriasis - drug therapy ; Psoriasis - pathology ; PUVA ; PUVA Therapy ; Severity of Illness Index ; Skin, nail, hair, dermoskeleton ; Spain ; Treatment Outcome</subject><ispartof>The Journal of dermatological treatment, 2004-04, Vol.15 (2), p.98-103</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-fbd3ba05614c024d7d814cdf676919069bd83517314db815c3df3850c476dedf3</citedby><cites>FETCH-LOGICAL-c347t-fbd3ba05614c024d7d814cdf676919069bd83517314db815c3df3850c476dedf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15621033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15204160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torras, H</creatorcontrib><creatorcontrib>Aliaga, A</creatorcontrib><creatorcontrib>López-Estebaranz, JL</creatorcontrib><creatorcontrib>Hernández, I</creatorcontrib><creatorcontrib>Gardeazabal, J</creatorcontrib><creatorcontrib>Quintanilla, E</creatorcontrib><creatorcontrib>Mascaró, JM</creatorcontrib><title>A combination therapy of calcipotriol cream and PUVA reduces the UVA dose and improves the response of psoriasis vulgaris</title><title>The Journal of dermatological treatment</title><addtitle>J Dermatolog Treat</addtitle><description>BACKGROUND: The addition of calcipotriol ointment to PUVA therapy for psoriasis vulgaris results in a lower total UVA dose and a faster onset of response. The addition of calcipotriol cream to PUVA, however, has not been studied.
OBJECTIVE: To investigate whether combining calcipotriol cream with PUVA therapy has a UVA sparing effect.
METHODS: We performed a randomized, multicentre, vehicle-controlled, double-blind, 12-week comparative study including 120 patients with psoriasis covering 20-50% body surface area. The study consisted of a washout phase followed by a 10-week treatment phase. PUVA therapy three times weekly was added within 1 week after randomization. Efficacy was assessed by the Psoriasis Area and Severity Index (PASI).
RESULTS: At baseline the mean PASI scores were 17.5 and 19.2 in the calcipotriol and vehicle (placebo) groups, respectively. At the end of treatment, the mean PASI scores were 2.65 and 7.03 (p<0.01), respectively. A reduction in PASI score >90% was observed in 69% of the patients in the calcipotriol-treated group and in 36.4% of the patients in the vehicle group (p<0.01).
CONCLUSION: Calcipotriol cream plus PUVA clearly reduces the cumulative dose of UVA and improves the response of psoriasis vulgaris to PUVA.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Calcipotriol</subject><subject>Calcitriol - administration & dosage</subject><subject>Calcitriol - analogs & derivatives</subject><subject>Clinical trial</subject><subject>Combined Modality Therapy</subject><subject>Comparative study</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Photochemotherapy</subject><subject>Psorias</subject><subject>Psoriasis - drug therapy</subject><subject>Psoriasis - pathology</subject><subject>PUVA</subject><subject>PUVA Therapy</subject><subject>Severity of Illness Index</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Spain</subject><subject>Treatment Outcome</subject><issn>0954-6634</issn><issn>1471-1753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kE9v1DAQxS0EokvhA3BBvsAtMI4dJyu4rCr-SZXgQLlGE9thXTlxGCet9tvj7QYBQurJY73fex4_xp4LeC2ggTewrZTWEpQAKKUsywdsI1QtClFX8iHbHPUiA-qMPUnpGkBIDc1jdiaqMps0bNhhx00cOj_i7OPI570jnA489txgMH6KM_kYuCGHA8fR8q9X33ecnF2MS0ecH-82Jnen-mGieLMq5NIUx6zktClF8ph84jdL-IHk01P2qMeQ3LP1PGdXH95_u_hUXH75-Plid1kYqeq56DsrO4RKC2WgVLa2TZ5sr2u9FVvQ2842shK1FMp2jaiMtL1sKjCq1tbl-Zy9OuXmzX4uLs3t4JNxIeDo4pJarbXSlZQZFCfQUEyJXN9O5AekQyugPfbd_td39rxYw5ducPaPYy04Ay9XAFNutCccjU9_cboUcPf4uxPnxz7SgLeRgm1nPIRIv03yvj3e_mPfOwzz3iC59jouNOaC7_nFL2jErWY</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Torras, H</creator><creator>Aliaga, A</creator><creator>López-Estebaranz, JL</creator><creator>Hernández, I</creator><creator>Gardeazabal, J</creator><creator>Quintanilla, E</creator><creator>Mascaró, JM</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>A combination therapy of calcipotriol cream and PUVA reduces the UVA dose and improves the response of psoriasis vulgaris</title><author>Torras, H ; Aliaga, A ; López-Estebaranz, JL ; Hernández, I ; Gardeazabal, J ; Quintanilla, E ; Mascaró, JM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-fbd3ba05614c024d7d814cdf676919069bd83517314db815c3df3850c476dedf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Calcipotriol</topic><topic>Calcitriol - administration & dosage</topic><topic>Calcitriol - analogs & derivatives</topic><topic>Clinical trial</topic><topic>Combined Modality Therapy</topic><topic>Comparative study</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Photochemotherapy</topic><topic>Psorias</topic><topic>Psoriasis - drug therapy</topic><topic>Psoriasis - pathology</topic><topic>PUVA</topic><topic>PUVA Therapy</topic><topic>Severity of Illness Index</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Spain</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torras, H</creatorcontrib><creatorcontrib>Aliaga, A</creatorcontrib><creatorcontrib>López-Estebaranz, JL</creatorcontrib><creatorcontrib>Hernández, I</creatorcontrib><creatorcontrib>Gardeazabal, J</creatorcontrib><creatorcontrib>Quintanilla, E</creatorcontrib><creatorcontrib>Mascaró, JM</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of dermatological treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torras, H</au><au>Aliaga, A</au><au>López-Estebaranz, JL</au><au>Hernández, I</au><au>Gardeazabal, J</au><au>Quintanilla, E</au><au>Mascaró, JM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A combination therapy of calcipotriol cream and PUVA reduces the UVA dose and improves the response of psoriasis vulgaris</atitle><jtitle>The Journal of dermatological treatment</jtitle><addtitle>J Dermatolog Treat</addtitle><date>2004-04</date><risdate>2004</risdate><volume>15</volume><issue>2</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>0954-6634</issn><eissn>1471-1753</eissn><abstract>BACKGROUND: The addition of calcipotriol ointment to PUVA therapy for psoriasis vulgaris results in a lower total UVA dose and a faster onset of response. The addition of calcipotriol cream to PUVA, however, has not been studied.
OBJECTIVE: To investigate whether combining calcipotriol cream with PUVA therapy has a UVA sparing effect.
METHODS: We performed a randomized, multicentre, vehicle-controlled, double-blind, 12-week comparative study including 120 patients with psoriasis covering 20-50% body surface area. The study consisted of a washout phase followed by a 10-week treatment phase. PUVA therapy three times weekly was added within 1 week after randomization. Efficacy was assessed by the Psoriasis Area and Severity Index (PASI).
RESULTS: At baseline the mean PASI scores were 17.5 and 19.2 in the calcipotriol and vehicle (placebo) groups, respectively. At the end of treatment, the mean PASI scores were 2.65 and 7.03 (p<0.01), respectively. A reduction in PASI score >90% was observed in 69% of the patients in the calcipotriol-treated group and in 36.4% of the patients in the vehicle group (p<0.01).
CONCLUSION: Calcipotriol cream plus PUVA clearly reduces the cumulative dose of UVA and improves the response of psoriasis vulgaris to PUVA.</abstract><cop>Oslo</cop><pub>Informa UK Ltd</pub><pmid>15204160</pmid><doi>10.1080/09546630410023322</doi><tpages>6</tpages></addata></record> |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Administration, Cutaneous Adult Biological and medical sciences Calcipotriol Calcitriol - administration & dosage Calcitriol - analogs & derivatives Clinical trial Combined Modality Therapy Comparative study Dermatologic Agents - administration & dosage Double-Blind Method Female Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Photochemotherapy Psorias Psoriasis - drug therapy Psoriasis - pathology PUVA PUVA Therapy Severity of Illness Index Skin, nail, hair, dermoskeleton Spain Treatment Outcome |
| title | A combination therapy of calcipotriol cream and PUVA reduces the UVA dose and improves the response of psoriasis vulgaris |
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