Efficacy of 3,4,3-LIHOPO for reducing neptunium retention in the rat after simulated wound contamination

Purpose: The ligand 3,4,3-Li(1,2-HOPO) was tested for Np removal after intramuscular injection of 237 Np nitrate in rats. Materials and methods: Two experiments were performed, one with simultaneous injection of neptunium and LIHOPO at dosages ranging from 3 to 200mumolkg -1 and the other with delay...

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Published in:International journal of radiation biology 2000, Vol.76 (1), p.113-117
Main Author: Paquet, B. Montegue, E. Ansoborlo, M. H. Henge-Napoli, P. Houpert, P. W. Durbin, K. N. Raymond, F.
Format: Article
Language:English
Subjects:
Animals
Aza Compounds - pharmacology
Biological and medical sciences
Biological effects of radiation
Bone and Bones - metabolism
Chelating Agents - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Injections, Intramuscular
Ionizing radiations
Kidney - metabolism
Liver - metabolism
Male
Neptunium - metabolism
Neptunium - pharmacology
Pyridones - pharmacology
Rats
Rats, Sprague-Dawley
Space life sciences
Time Factors
Tissues, organs and organisms biophysics
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Summary:Purpose: The ligand 3,4,3-Li(1,2-HOPO) was tested for Np removal after intramuscular injection of 237 Np nitrate in rats. Materials and methods: Two experiments were performed, one with simultaneous injection of neptunium and LIHOPO at dosages ranging from 3 to 200mumolkg -1 and the other with delayed administration of LIHOPO 30mumolkg -1 from 5min to 30min after Np injection. Results: The data obtained after simultaneous injections showed that the ligand dosage effectiveness was not linear and depended on the tissues being considered. For bones, the best results were obtained with 200 mumolkg -1 LIHOPO, where retention was reduced to 11% of controls. Maximum efficacies for removal in liver and kidney were obtained with 30mumol kg -1 LIHOPO, where retention was reduced to 39% and 1.6% of controls, respectively. At higher dosages, LIHOPO seemed to have a reverse effect on these tissues, demonstrated by a significant accumulation of the radionuclide. The delayed administration of LIHOPO dramatically decreased its efficacy. When administered 5min after Np, LIHOPO was still efficient (60%, 37%, 7% of controls in bone, liver, kidneys, respectively) but not when treatment was delayed to 30min. Conclusions: These results demonstrated that LIHOPO was able to complex Np at the wound site but not after translocation to blood.
ISSN:0955-3002
1362-3095
DOI:10.1080/095530000139078