A new elemanolide sesquiterpene lactone from Elephantopus scaber

A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three...

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Bibliographic Details
Published in:Journal of asian natural products research 2008-05, Vol.10 (5), p.403-407
Main Authors: Liang, Qiao-Li, Min, Zhi-Da, Tang, Yu-Ping
Format: Article
Language:English
Subjects:
anticancer
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Asteraceae - chemistry
Biological and medical sciences
Cell Line, Tumor
Compositae
Drugs, Chinese Herbal - chemistry
Elephantopus
Elephantopus scaber
elescaberin
General pharmacology
Humans
Lactones - chemistry
Lactones - isolation & purification
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
sesquiterpene lactone
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes, Germacrane - isolation & purification
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Summary:A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC 50 8.18-14.08 μmol/l).
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020801966526