Syntheses of 1,5-Benzothiazepines: Part XXIV- Syntheses of 4-(4-Chlorophenyl)-2-(4-Dimethyl-Aminophenyl)-2,5-Dihydro-8-Substituted-1,5-Benzothiazepines

Single step syntheses of 4-(4-chlorophenyl)-2-(4-dimethylaminophenyl)-2,5-dihydro-8-substituted-1,5- benzothiazepines have been achieved by the reactions of five 5-substituted-2-aminobenzenethiols with 4-dimethyl aminobenzal-4′-chloroacetophenone in ethanol saturated with HCI gas. The structural ass...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2000-01, Vol.167 (1), p.1-8
Main Authors: Pant, Umesh C., Singhal, Babita, Sati, Meha, Pant, Seema
Format: Article
Language:English
Subjects:
1:5-benzothiazepine
cardiovascular
Chemotherapeutic
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Summary:Single step syntheses of 4-(4-chlorophenyl)-2-(4-dimethylaminophenyl)-2,5-dihydro-8-substituted-1,5- benzothiazepines have been achieved by the reactions of five 5-substituted-2-aminobenzenethiols with 4-dimethyl aminobenzal-4′-chloroacetophenone in ethanol saturated with HCI gas. The structural assignments of the final products are based on the results of elemental analyses, IR. 1 H NMR and mass spectral studies.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500008082382