Synthesis and Antimicrobial Activity of Thioxopyrimidines and Related Derivatives

The interaction of thiourea with activated cyanoolefins under different reaction conditions were studied, in which a variety of thiopyrimidines (8, 9, 12, 18, 20, & 21) and related derivatives (10, 11, 14, 16, & 17) were obtained respectively. Also, the reactions of thiopyrimidines (8, 9) wi...

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Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2006-04, Vol.181 (4), p.839-864
Main Authors: El-Agrody, Ahmed M., Ali, Fawzy M., Eid, Fathy A., El-Nassag, Mohammed A. A., El-Sherbeny, Gamal, Bedair, Ahmed H.
Format: Article
Language:English
Subjects:
(1H-pyrazol-1-yl)pyrimidine
[(pyrimidin-2-yl)disulfanyl] pyrimidine
Activated nitriles
antimicrobial activities
thiourea
thioxopyrimidines
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Summary:The interaction of thiourea with activated cyanoolefins under different reaction conditions were studied, in which a variety of thiopyrimidines (8, 9, 12, 18, 20, & 21) and related derivatives (10, 11, 14, 16, & 17) were obtained respectively. Also, the reactions of thiopyrimidines (8, 9) with different electrophilic and nucleophilic reagents were reported. IR, 1 H NMR, 13 C NMR and mass spectra for the newly synthesized compounds were studied. Most of the obtained compounds were screened against Gram-postive and Gram-negative bacteria and fungi, for which some of these derivatives gave promising results.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500500272087