Novel Quinazolinone Derivatives as Possible Antitumor Agents

The synthesis of a novel series of quinazolinone derivatives 6-15 having the biologically active thioxo group utilizing 2-isothiocyanato-benzoic acid methyl ester 2 is reported. Their structures have been confirmed on the basis of elemental analyses and (IR, 1 H NMR, and mass) spectral data. Prelimi...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2007-01, Vol.182 (1), p.65-77
Main Authors: Barakat, Saber El-Sayed, Ghorab, Moustafa M., Saker, Helmy M., Abd Rabo, Mahmoud M.
Format: Article
Language:English
Subjects:
Antitumor activity
quinazoline-4(3H)-one
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Summary:The synthesis of a novel series of quinazolinone derivatives 6-15 having the biologically active thioxo group utilizing 2-isothiocyanato-benzoic acid methyl ester 2 is reported. Their structures have been confirmed on the basis of elemental analyses and (IR, 1 H NMR, and mass) spectral data. Preliminary testing for the in vitro antitumor activity of some synthesized compounds against Ehrlich Ascities Carcinoma cells was carried out.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500600867042