Synthesis, Anti-HIV, and Antifungal Activity of New Benzensulfonamides Bearing the 2,5-Disubstituted-1,3,4-Oxadiazole Moiety

A series of novel chiral and achiral N-[1-(1,3,4-oxadiazol-2ylthio)alkyl]-4-methyl/chloro/methoxybenzenesulfonamides 5a-l were prepared by the reaction of 4-(4-methyl, chloro, methoxyphenylsulfonamido)alkyl carboxylic acid hydrazides 4a-l with CS 2 and KOH. Another series of new secondary benzenesul...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2007-02, Vol.182 (2), p.281-298
Main Authors: Zareef, Muhammad, Iqbal, Rashid, Al-Masoudi, Najim A., Zaidi, Javid H., Arfan, Muhammad, Shahzad, Sohail A.
Format: Article
Language:English
Subjects:
1,3,4-oxadiazole
anti-HIV activity
Antifungal activity
benezenesulfonamides chiral sulfonamides
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Summary:A series of novel chiral and achiral N-[1-(1,3,4-oxadiazol-2ylthio)alkyl]-4-methyl/chloro/methoxybenzenesulfonamides 5a-l were prepared by the reaction of 4-(4-methyl, chloro, methoxyphenylsulfonamido)alkyl carboxylic acid hydrazides 4a-l with CS 2 and KOH. Another series of new secondary benzenesulfonamides 10a-j and bis-benzenesulfonamides 11a-j have been synthesized by a new approach using Et 3 N and dimethylaminopyridine. All synthesized compounds were characterized by physical, microanalytical, and spectral data. Some of the synthesized compounds were screened in vitro for their anti-HIV and antifungal activities.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500600919074