Bismuth Chloride Mediated Synthesis, Antimicrobial, and Anti-Inflammatory Activities of New 4-Aryl-2-Amino Thiazoles

Synthesis of 4-aryl-2-Amino thiazoles (3a-u), (4a-c), and (5a-c) was achieved from the reaction of 4-butyl phenacyl chlorides (2a-c) with N-substituted thioureas, in the presence of Bismuth Chloride. The antimicrobial and anti-inflammatory activities of the final products were also studied.

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2008-07, Vol.183 (8), p.2058-2072
Main Authors: Giridhar, T., Reddy, R. Buchi, Kumar, A. Sunil, Chandra Mouli, G. V. P.
Format: Article
Language:English
Subjects:
4-aryl-2-amino thiazoles
4-butyl phenacyl chlorides
Bismuth chloride
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Summary:Synthesis of 4-aryl-2-Amino thiazoles (3a-u), (4a-c), and (5a-c) was achieved from the reaction of 4-butyl phenacyl chlorides (2a-c) with N-substituted thioureas, in the presence of Bismuth Chloride. The antimicrobial and anti-inflammatory activities of the final products were also studied.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500701842019