Synthesis and Inhibitory Activity Against Epstein-Barr Virus of Some New 1,2,3,4-Tetrahydropyrimidine-2-thiones

1,2,3,4-Tetrahydropyrimidine-2-thiones 4a-n were synthesized through the reaction of aromatic aldehydes 1a-n , ethyl acetoacetate (2) and thiourea ( 3) . The structures of all newly synthesized heterocyclic compounds elucidated by the use of IR, 1 H NMR, mass spectra, and elemental analyses. The inh...

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Bibliographic Details
Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2008-11, Vol.183 (12), p.2956-2967
Main Authors: Attaby, Fawzy A., Ramla, Mostafa M., Harukuni, T.
Format: Article
Language:English
Subjects:
1,2,3,4-tetrahydropyrimidinethione
and thiourea
antigen
Epstein-Barr Virus
ethylaceto-acetate
inhibitory activity
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Summary:1,2,3,4-Tetrahydropyrimidine-2-thiones 4a-n were synthesized through the reaction of aromatic aldehydes 1a-n , ethyl acetoacetate (2) and thiourea ( 3) . The structures of all newly synthesized heterocyclic compounds elucidated by the use of IR, 1 H NMR, mass spectra, and elemental analyses. The inhibitory activity against the Epstein-Barr Virus early antigen (EBA-VA) of all newly synthesized heterocyclic compounds were evaluated.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500802043152