Synthesis and Anti-Inflammatory Activities of Some Novel S-Pyridyl Glycosides Derivatives

A series of some new acetylated S-glycosides of pyridine-2-thione derivatives, including D-glucose, D-galactose, D-xylose and L-arabinose derivatives were synthesized. Oxidation of some formed S-glycosides derivatives with H 2 O 2 afforded the corresponding sulfones. S-Alkylation of pyridine-2-thion...

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Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2008-11, Vol.183 (12), p.3046-3062
Main Authors: Khalifa, Nagy M., Ramla, Mostafa M., Amr, Abd El-Galil E., Abdulla, Mohamed M.
Format: Article
Language:English
Subjects:
5,6,7,8-Tetrahydronaphthalene
Anti-inflammatory activity
glycoside derivatives
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Summary:A series of some new acetylated S-glycosides of pyridine-2-thione derivatives, including D-glucose, D-galactose, D-xylose and L-arabinose derivatives were synthesized. Oxidation of some formed S-glycosides derivatives with H 2 O 2 afforded the corresponding sulfones. S-Alkylation of pyridine-2-thione derivatives was performed to furnish the S-acyclo deazauridine derivatives. The entire tested compound showed potent anti-inflammatory activity were potent against edema and in the same time inhibited the prostaglandine formation. It is work mention that all the tested compounds showed high safety margin. The structures of the new synthesized compounds have been proved by IR, 1 HNMR, mass spectra and elemental analysis.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500802059885