2-Thieno/Selenopyrano[2,3-b]quinolines: Microwave-Induced One-Pot Synthesis, DNA Binding, and Photocleavage Studies

We have characterized a new class of 2-thieno/2-selenopyrano[2,3-b]quinolin-2-ol (2c/3c) intercalators exhibiting a novel type of DNA binding and photocleavage activity. The dynamic behavior of these compounds with DNA was investigated by absorption spectra (obtained K b constant for 2c is 3.6 × 10...

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Published in:Phosphorus, sulfur, and silicon and the related elements sulfur, and silicon and the related elements, 2009-10, Vol.184 (10), p.2583-2593
Main Authors: Naik, H. R. Prakash, Naik, H. S. Bhojya, Naik, T. R. Ravikumar, Aravinda, T., Lamani, D. S., Naika, H. Raja
Format: Article
Language:English
Subjects:
CT-DNA-binding-photocleavege
thieno-seleno-quinoline
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Summary:We have characterized a new class of 2-thieno/2-selenopyrano[2,3-b]quinolin-2-ol (2c/3c) intercalators exhibiting a novel type of DNA binding and photocleavage activity. The dynamic behavior of these compounds with DNA was investigated by absorption spectra (obtained K b constant for 2c is 3.6 × 10 6 and for 3c is 2.8 × 10 5 ), viscosity, and thermal denaturation studies. Intrinsic binding constants (K b ) have been estimated under a similar set of experimental conditions. An absorption spectral study shows the strong interaction between synthesized 2c, 3c, and base pairs CT-DNA. In addition, the effects of these compounds on DNA cleavage were investigated by photoirradiation at 360 nm and show that the hybrids effectively cleaved double-stranded DNA with UV light of a long wavelength and without any additive.
ISSN:1042-6507
1563-5325
DOI:10.1080/10426500802529622