Acute Disseminated Encephalomyelitis After Para-influenza Infection Post Bone Marrow Transplantation

Acute disseminated encephalomyelitis (ADEM) is a parainfectious or postvaccination demyelinating condition, characterized by rapid onset of multifocal neurological deficits, usually occurring in childhood or adolescence. We report case of ADEM in an allogeneic bone marrow transplant recipient, who p...

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Bibliographic Details
Published in:Leukemia & lymphoma 2002, Vol.43 (2), p.455-457
Main Authors: Au, Wing Y., Lie, Albert K.W., Cheung, Raymond T.F., Cheng, P.W., Ooi, Clara G.C., Yuen, Kwok-Yung, Kwong, Yok-Lam
Format: Article
Language:English
Subjects:
Acute Disseminated Encephalomyelitis
Adult
Bone Marrow Transplantation
Bone Marrow Transplantation - adverse effects
Chronic Graft Versus Host Disease
Encephalomyelitis, Acute Disseminated - diagnosis
Encephalomyelitis, Acute Disseminated - etiology
Encephalomyelitis, Acute Disseminated - virology
Graft vs Host Disease - virology
Humans
Magnetic Resonance Imaging
Male
Opportunistic Infections - etiology
Opportunistic Infections - virology
Para-influenza Virus
Parainfluenza Virus 3, Human
Respirovirus Infections - etiology
Transplantation, Homologous - adverse effects
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Summary:Acute disseminated encephalomyelitis (ADEM) is a parainfectious or postvaccination demyelinating condition, characterized by rapid onset of multifocal neurological deficits, usually occurring in childhood or adolescence. We report case of ADEM in an allogeneic bone marrow transplant recipient, who presented with rapid onset of paraplegia and widespread neurological deficits 6 weeks after parainfluenza pneumonia. Magnetic resonance imaging (MRI) showed typical features of ADEM, involving the subcortical white matter, brain steam and spinal cord. There was a rapid and complete response to pulse high-dose corticosteriod and intravenous immunoglobulin. The importance of recognition and early treatment of this rare condition in transplantation practice is emphasized.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428190290006350