Stain and dye stability over a 30-year period: a comparison of certified dye powders by the Biological Stain Commission

The Biological Stain Commission (BSC) Assay Laboratory has received numerous inquiries during the past several years regarding the long-term stability of stain and dye powders, particularly since packaging requirements call for expiration dates on reagents. We have conducted a study to examine the l...

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Bibliographic Details
Published in:Biotechnic & histochemistry 2009-01, Vol.84 (1), p.11-15
Main Authors: Penney, DP, Frank, M, Fagan, C, Willis, C
Format: Article
Language:English
Subjects:
Certification
certified stains
Coloring Agents - standards
dye stability
GLP
GMP
Indicators and Reagents
Powders
Quality Control
shelf-life
Staining and Labeling
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Summary:The Biological Stain Commission (BSC) Assay Laboratory has received numerous inquiries during the past several years regarding the long-term stability of stain and dye powders, particularly since packaging requirements call for expiration dates on reagents. We have conducted a study to examine the long-term stability of selected dye powders. We used the standard procedures of the BSC for testing biological stains for certification to give an indication of the long-term chemical stability as well as staining performance of the dye powders. An earlier study by Emmel and Stotz examined the stability of various dye powders after a five-year storage period. The present study is a follow-up project covering the same dyes after storage for 30 years. The dye samples chosen for the study are the same samples used in the five-year storage period study and give comparative results for all three time periods. The results of this study affirm the generally held speculation that dye powders are stable for many years and thus have a substantial shelf-life.
ISSN:1052-0295
1473-7760
DOI:10.1080/10520290802630415