Evaluation of the uncertainty of molecular mass measurement by electrospray ionization mass spectrometry

Electrospray ionization (ES) is a novel method used in mass spectrometry (MS) for producing gas-phase ions from substances in solutions. Common practices for molecular mass estimation from ES spectra summarize the spectrum as a single peak giving no estimate of uncertainty or treat each peak as an i...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biopharmaceutical statistics 1997, Vol.7 (3), p.453-465
Main Authors: Juneau, Paul L., Giordani, Anne B., Pyne1, David A.
Format: Article
Language:English
Subjects:
Animals
Autocorrelation
Chemistry, Physical - methods
Durbin-Watson test
Electrospray mass spectrometry
Horses
Linear Models
Mass measurement uncertainty
Mass Spectrometry - methods
Molecular Weight
Myocardium - chemistry
Myoglobin - chemistry
Statistics as Topic - methods
Time-series data
Yule-Walker equations
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Electrospray ionization (ES) is a novel method used in mass spectrometry (MS) for producing gas-phase ions from substances in solutions. Common practices for molecular mass estimation from ES spectra summarize the spectrum as a single peak giving no estimate of uncertainty or treat each peak as an independent molecular mass measurement. ES-MS data analysis showed that each peak in an ES spectrum does not always provide an independent measure of molecular mass. Underestimation of measurement uncertainty is a possible result. An elementary time series method, the Yule-Walker equations, was applied to molecular mass estimation from ES data.
ISSN:1054-3406
1520-5711
DOI:10.1080/10543409708835200