Fungal Transformations of Steroids by Cephalosporium Aphidicola and Trichothecium Roseum

Transformation of dehydroepiandrosterone (1) was carried out by incubation with the fungus Cephalosporium aphidicola to obtain 3β-hydroxyandrost-4-en-17-one (2) and 3β,4β-dihydroxyandrost-5-en-17-one (3). The fermentation of androsterone (4) by Trichothecium roseum afforded 3α, 17β-dihydroxyandrosta...

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Bibliographic Details
Published in:Natural product letters 2000-03, Vol.14 (3), p.217-224
Main Authors: Atta-Ur-Rahman, Choudhary, M. Iqbal, Asif, Fahim, Farooq, Afgan, Yaqoob, M.
Format: Article
Language:English
Subjects:
17β-dihydronyandrostane
3β,4β-dihydroxyand-rost-5-en-17-one
3β-hydroxyandrost-4-en-17-one
androsterone
Cephalosporium aphidicola
dehydroepiandrosterone
Fungal transformation
Trichothecium roseum
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Summary:Transformation of dehydroepiandrosterone (1) was carried out by incubation with the fungus Cephalosporium aphidicola to obtain 3β-hydroxyandrost-4-en-17-one (2) and 3β,4β-dihydroxyandrost-5-en-17-one (3). The fermentation of androsterone (4) by Trichothecium roseum afforded 3α, 17β-dihydroxyandrostane (5).
ISSN:1057-5634
DOI:10.1080/10575630008041234