Steroid and Antibacterial Steroidal Glycosides from Marine Green Alga Codium Iyengarii Borgesen

The ethyl acetate soluble part of methanolic extract of marine green alga Codium iyengarii collected from Karachi coast of Arabian Sea afforded a new steroid ( 1 , iyengadione) and two new steroidal glycosides [iyengaroside-A ( 2 ) and B ( 3 )] along with clerosterol galactoside ( 4 ). Their structu...

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Bibliographic Details
Published in:Natural product letters 2002-12, Vol.16 (6), p.407-413
Main Authors: Ali, Muhammad Shaiq, Saleem, Muhammad, Yamdagni, Raghav, Ali, Muhammad Ashfaq
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Arabian Sea
Bacteria - drug effects
Bactericidal Activity
Chlorophyta - chemistry
Codium
Codium Iyengarii
Dimethyl Sulfoxide
Galactosides - chemistry
Galactosides - isolation & purification
Galactosides - pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Green Alga
Inhibitory Concentration 50
Marine
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pakistan
Spectroscopy
Stereoisomerism
Steroidal-glycosides
Steroids
Steroids - chemistry
Steroids - isolation & purification
Steroids - pharmacology
Structure Elucidation
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Summary:The ethyl acetate soluble part of methanolic extract of marine green alga Codium iyengarii collected from Karachi coast of Arabian Sea afforded a new steroid ( 1 , iyengadione) and two new steroidal glycosides [iyengaroside-A ( 2 ) and B ( 3 )] along with clerosterol galactoside ( 4 ). Their structures were elucidated with the aid of 1D-NMR spectroscopy and reconfirmed through HMBC experiments. The bactericidal activity of 1 - 4 was also explored and found positive response from iyengaroside-A ( 2 ) and clerosterol galactoside ( 4 ).
ISSN:1057-5634
DOI:10.1080/10575630290034249