Effect of Vitamin E on Serum Aminotransferase and Thioredoxin Levels in Patients with Viral Hepatitis C

Objectives: Oxidative stress induces cellular responses such as cell death, gene activation and cell proliferation, in the liver. Vitamin E (Vit. E) has been found to protect the liver against oxidative stress in animal experiments. Thioredoxin (TRX) is a stress inducible, multifunctional protein, s...

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Published in:Free radical research 2003-07, Vol.37 (7), p.781-785
Main Authors: Mahmood, Sabina, Yamada, Gotaro, Niiyama, Gouichi, Kawanaka, Miwa, Togawa, Kazumi, Sho, Miho, Ito, Toshio, Sasagawa, Takayo, Okita, Misako, Nakamura, Hajime, Yodoi, Junji
Format: Article
Language:English
Subjects:
Aged
Alanine Transaminase - blood
alpha-Tocopherol - pharmacology
ALT
Female
Hepatitis C - blood
Hepatitis C - enzymology
Humans
Interferons - pharmacology
Male
Middle Aged
Oxidative Stress
Thioredoxin
Thioredoxins - blood
Time Factors
Viral hepatitis C oxidative stress
Vitamin E
Vitamin E - metabolism
Vitamin E - pharmacology
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Summary:Objectives: Oxidative stress induces cellular responses such as cell death, gene activation and cell proliferation, in the liver. Vitamin E (Vit. E) has been found to protect the liver against oxidative stress in animal experiments. Thioredoxin (TRX) is a stress inducible, multifunctional protein, secreted during oxidative stress. This study evaluated effects of Vit. E on serum TRX and aminotransferase levels in hepatitis C virus (HCV) patients, partly non-responsive to initial interferon (IFN), with higher than average level of serum alanine aminotransferase (ALT) after receiving anti-inflammatory drug treatment. Methods: Seventeen HCV patients (male=3; female=14) of age 62±7.65 years receiving anti-inflammatory drug therapy, at least 6 months prior to Vit. E administration, were given d- ´-tocopherol 500 mg/day, orally, for a period of 3 months. ALT, aspartate aminotransferase (AST), TRX and Vit. E were measured at 0, 1, 2 and 3 months and 1 month after end of treatment. As controls, the same patients biochemical data, 3 months from the start of therapy were used. Patients were divided into three categories: total patients "T", low ALT group "L" (ALT70 IU/l), respectively.Results: The ALT level was lowered, significantly in group H, in the 1st, 2nd, 3rd and 1-month post therapy, compared to the initial value. But group L showed little or no change in ALT. Post Vit. E therapy, in groups T and H, the TRX level was elevated but remained below initial levels, whereas in group L, TRX level remained significantly lower than the pretreatment value. Groups T and L, showed significant reduction (p
ISSN:1071-5762
1029-2470
DOI:10.1080/1071576031000102141