Ammonio Polymethacrylate-Coated Diltiazem: Drug Release from Single Pellets, Media Dependence, and Swelling Behavior

Drug release from single pellets was measured on an easily assembled flow-through system. Despite heterogeneity between pellets, the sum of the individual results resembled drug release from an ensemble. A typical pellet displayed a long lag followed by rapid release. Heterogeneity appeared to resul...

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Bibliographic Details
Published in:Pharmaceutical development and technology 2007-01, Vol.12 (3), p.285-296
Main Authors: Heinicke, Grant, Schwartz, Joseph B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calcium Channel Blockers - chemistry
Diltiazem - chemistry
Drug Implants
drug release
General pharmacology
Medical sciences
multiparticulate
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymethacrylic Acids - chemistry
Quaternary Ammonium Compounds - chemistry
Single-pellet dissolution
swelling
Time Factors
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Summary:Drug release from single pellets was measured on an easily assembled flow-through system. Despite heterogeneity between pellets, the sum of the individual results resembled drug release from an ensemble. A typical pellet displayed a long lag followed by rapid release. Heterogeneity appeared to result from substrate properties rather than coating uniformity. Swelling behavior in acid and buffer was measured by dynamic image analysis and related to drug release. Drug release was sensitive to dissolution temperature but swelling was not. A description of the drug release process was proposed.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450701247384