Ammonio Polymethacrylate-Coated Diltiazem: Drug Release from Single Pellets, Media Dependence, and Swelling Behavior

Drug release from single pellets was measured on an easily assembled flow-through system. Despite heterogeneity between pellets, the sum of the individual results resembled drug release from an ensemble. A typical pellet displayed a long lag followed by rapid release. Heterogeneity appeared to resul...

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Published in:Pharmaceutical development and technology 2007-01, Vol.12 (3), p.285-296
Main Authors: Heinicke, Grant, Schwartz, Joseph B.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Calcium Channel Blockers - chemistry
Diltiazem - chemistry
Drug Implants
drug release
General pharmacology
Medical sciences
multiparticulate
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymethacrylic Acids - chemistry
Quaternary Ammonium Compounds - chemistry
Single-pellet dissolution
swelling
Time Factors
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cited_by cdi_FETCH-LOGICAL-c434t-94aabaaeffc3e839fe5a99d812dad66c4b40fc59c4b82bcc9a12348fdc41a56a3
cites cdi_FETCH-LOGICAL-c434t-94aabaaeffc3e839fe5a99d812dad66c4b40fc59c4b82bcc9a12348fdc41a56a3
container_end_page 296
container_issue 3
container_start_page 285
container_title Pharmaceutical development and technology
container_volume 12
creator Heinicke, Grant
Schwartz, Joseph B.
description Drug release from single pellets was measured on an easily assembled flow-through system. Despite heterogeneity between pellets, the sum of the individual results resembled drug release from an ensemble. A typical pellet displayed a long lag followed by rapid release. Heterogeneity appeared to result from substrate properties rather than coating uniformity. Swelling behavior in acid and buffer was measured by dynamic image analysis and related to drug release. Drug release was sensitive to dissolution temperature but swelling was not. A description of the drug release process was proposed.
doi_str_mv 10.1080/10837450701247384
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subjects Biological and medical sciences
Calcium Channel Blockers - chemistry
Diltiazem - chemistry
Drug Implants
drug release
General pharmacology
Medical sciences
multiparticulate
Particle Size
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymethacrylic Acids - chemistry
Quaternary Ammonium Compounds - chemistry
Single-pellet dissolution
swelling
Time Factors
title Ammonio Polymethacrylate-Coated Diltiazem: Drug Release from Single Pellets, Media Dependence, and Swelling Behavior
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