Psychiatric symptoms and diagnoses in thyroid disorders: a cross-sectional study

• Published in: International journal of psychiatry in clinical practice 2005, Vol.9 (3), p.187-192
• Main Authors: Aslan, Selcuk, Ersoy, Reyhan, Kuruoglu, Asli Cepik, Karakoc, Ayhan, Cakir, Nuri
• Format: Article
• Language: English
• Subjects: anxiety; depression; hyperthyroidism; hypothyroidism; psychopathology; Thyroid disorders
• ISSN: 1365-1501; 1471-1788
• DOI: 10.1080/13651500510029129

Objective Endocrine dysfunction may produce symptoms that are difficult to distinguish from the clinical manifestations of psychiatric disorders. In particular, the function of the hypothalamic-pituitary-thyroidal axis is known to be associated with a number of psychiatric abnormalities, such as depression and anxiety. In this study, we tested the hypothesis that depression is more commonly encountered in hypothyroidism, while anxiety is more prevalent in hyperthyroidism. Additionally, we aimed to evaluate the correlations of the intensity of the psychiatric symptomatology in these patients with the specific parameters of thyroid function, such as levels of TSH, T3 and T4. Method Patients newly diagnosed as having thyroid disorders were included in the study. They were classified into five study groups (according to the results of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) and autoantibody (anti-thyroglobulin antibodies and anti-microsomal antibodies) measurements): hypothyroid, hyperthyroid, subclinical hypothyroid, subclinical hyperthyroid, and euthyroid Hashimoto's thyroiditis. Psychopathological symptoms were evaluated on the 17-item Hamilton Rating Scale for Depression (HDRS), Brief Symptom Inventory (BSI), BSI Sub-scales and Hospital Anxiety and Depression Scale (HAD). Psychiatric diagnoses were performed using DSM-IV-SCID (Structured Clinical Interview for DSM). The relationship between the results of the psychiatric evaluation and thyroid function tests was assessed statistically by ANOVA and Pearson correlation tests. Results Eighty patients (68 female and 12 male), with a mean age of 42.5±13.4 years, were evaluated. A positive correlation between the total BSI scores and TSH levels (r = 0.65, P = 0.01) was noted in the hypothyroid (n=25) group. Hyperthyroid patients (n=22) showed a positive correlation between HDRS scores and fT4 levels (r = 0.62, P = 0.01). The BSI scores in hypo- and hyperthyroidism were significantly higher than normal (P