Genotoxicity Induced by Eugenia Caryophyllata Infusion

Several therapeutic properties have been described for Eugenia caryophyllata (clove). In the present study the infusion of E. caryophyllata was evaluated in a series of bacterial and cell-free assays in order to determine genotoxic potential. Negative results were obtained in the SOS chromotest and...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2008-01, Vol.71 (7), p.439-444
Main Authors: Estevam dos Santos, Patrícia, Carmem Monte Egito, Lucila, Batistuzzo de Medeiros, Sílvia Regina, Agnez-Lima, Lucymara Fassarella
Format: Article
Language:English
Subjects:
Beverages - toxicity
Cytotoxicity
DNA Damage - drug effects
Escherichia coli - drug effects
Escherichia coli - genetics
Eugenia
Mutagenicity Tests - methods
Mutagens - analysis
Plant Extracts - toxicity
Salmonella - drug effects
Salmonella - genetics
Syzygium - toxicity
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Summary:Several therapeutic properties have been described for Eugenia caryophyllata (clove). In the present study the infusion of E. caryophyllata was evaluated in a series of bacterial and cell-free assays in order to determine genotoxic potential. Negative results were obtained in the SOS chromotest and in the Salmonella reversion assay using strains TA97a, TA98, TA100, and TA102. However, in a forward mutagenesis assay an increase in mutagenesis and high cytotoxicity was observed with the CC104 mutMmutY strain, suggesting that oxidative DNA damage occurred. The treatment of plasmid with clove infusion showed that DNA strand breaks and sites recognized by formamidopyrimidine-DNA-glycosylase (FPG/MutM) were generated. Data suggest that the occurrence of oxidative DNA damage, with low mutagenic potential, may also be involved in the cytotoxicity attributed to clove infusion.
ISSN:1528-7394
1087-2620
DOI:10.1080/15287390701839232