Antibody Response for L1, E6, E7 HPV 16, and HPV 18 Antigens in Tunisian Women with Cervical Cancer

Results obtained in the present work indicated that the Luminex assay is more sensitive than ELISA. The reactivity to the early antigens E6 and E7 was 37% versus 42% for HPV 16 and 21% versus 20% for HPV 18 among cervical cancer cases using ELISA. However, these ratios were 44% and 61%, respectively...

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Bibliographic Details
Published in:Journal of immunoassay & immunochemistry 2009-01, Vol.30 (1), p.82-96
Main Authors: Achour, M., Zeghal, D., Kochbati, L., Kahla, S., Zouari, F., Maâlej, M., Oueslati, R.
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Antibody Formation - immunology
Capsid Proteins - immunology
ELISA
Female
HPV 16
HPV 18
Human papillomavirus
Human papillomavirus 16 - immunology
Human papillomavirus 18 - immunology
Humans
Luminex
Oncogene Proteins, Viral - immunology
Papillomavirus E7 Proteins - immunology
Papillomavirus Infections - epidemiology
Papillomavirus Infections - immunology
Papillomavirus Infections - virology
Repressor Proteins - immunology
Serology
Tunisia - epidemiology
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - immunology
Uterine Cervical Neoplasms - virology
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Summary:Results obtained in the present work indicated that the Luminex assay is more sensitive than ELISA. The reactivity to the early antigens E6 and E7 was 37% versus 42% for HPV 16 and 21% versus 20% for HPV 18 among cervical cancer cases using ELISA. However, these ratios were 44% and 61%, respectively, for E6 and E7 HPV 16 versus 28% and 21% for E6 and E7 HPV 18 when using the Luminex technique. Data also indicated that HPV 16 and HPV 18 showed distinct profiles for the different antigens tested. Finally, the differences in antibody responses between cervical cancer cases and benign cases toward the different antigens were significant.
ISSN:1532-1819
1532-4230
DOI:10.1080/15321810802569543