Pristine Fullerene C60: Different Water Soluble Forms-Different Mechanisms of Biological Action

Aqueous fullerene preparations, namely complex of C 60 with polyvinylpyrrolidone (C 60 /PVP) and molecular-colloidal water solutions of C 60 (FWS) exhibit virocidal activity due to different mechanisms: C 60 /PVP complexes act mainly on the lipid component of virus membranes, while the mechanism of...

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Published in:Fullerenes, nanotubes, and carbon nanostructures nanotubes, and carbon nanostructures, 2006-12, Vol.14 (2-3), p.327-333
Main Authors: Sirotkin, A. K., Zarubaev, V. V., Poznyiakova, L. N., Dumpis, M. A., Muravieva, T. D., Krisko, T. K., Belousova, I. M., Kiselev, O. I., Piotrovsky, L. B.
Format: Article
Language:English
Subjects:
colloidal solution
complex C
mechanism of action
polyvinylpyrrolidone
Pristine fullerene
virocidal activity
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Summary:Aqueous fullerene preparations, namely complex of C 60 with polyvinylpyrrolidone (C 60 /PVP) and molecular-colloidal water solutions of C 60 (FWS) exhibit virocidal activity due to different mechanisms: C 60 /PVP complexes act mainly on the lipid component of virus membranes, while the mechanism of virocidal action of FWS is mainly connected with the ability of fullerene to generate singlet oxygen under irradiation. In the first case, fullerene acts mainly as a membranotropic agent, whereas in the second case it acts mainly as a photosensitizer.
ISSN:1536-383X
1536-4046
DOI:10.1080/15363830600665375