Gender difference in the miotic potency of soman vapor in rats

The present study was undertaken to investigate the miotic potency of soman vapor in the rat, as well as gender differences in the miotic response to soman vapor that have been reported previously for other nerve agents. The results of the present study demonstrate that the miotic potency of soman v...

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Bibliographic Details
Published in:Cutaneous and ocular toxicology 2008-01, Vol.27 (2), p.123-133
Main Authors: Dabisch, Paul A., Horsmon, Michael S., Taylor, James T., Muse, William T., Miller, Dennis B., Sommerville, Douglas R., Mioduszewski, Robert J., Thomson, Sandra
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Acetylcholinesterase - blood
Analysis of Variance
Animals
Biological and medical sciences
Butyrylcholinesterase
Butyrylcholinesterase - blood
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical Warfare Agents - pharmacology
Cholinesterase Inhibitors - pharmacology
Eye - anatomy & histology
Eye - drug effects
Eye - enzymology
Female
Gas, fumes
Gender differences
Infrared Rays
Male
Medical sciences
Miosis
Miosis - chemically induced
Models, Animal
Nerve agent
Organophosphorus Compounds - pharmacology
Organothiophosphorus Compounds - pharmacology
Potency comparison
Pupil - drug effects
Pupil constriction
Rats
Rats, Sprague-Dawley
Sex Characteristics
Soman
Soman - pharmacology
Toxicology
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Summary:The present study was undertaken to investigate the miotic potency of soman vapor in the rat, as well as gender differences in the miotic response to soman vapor that have been reported previously for other nerve agents. The results of the present study demonstrate that the miotic potency of soman vapor is significantly less than that of other nerve agents, and that female rats are 2.5-3.0 times more sensitive to soman vapor than male rats. The results also demonstrate that ocular acetylcholinesterase and butyrylcholinesterase activities differ between males and females, although this difference is not likely large enough to account for the observed gender difference.
ISSN:1556-9527
1556-9535
DOI:10.1080/15569520802064376