DIFFERENTIAL PULSE VOLTAMMETRY FOR DETERMINATION OF PARACETAMOL AT A PUMICE MIXED CARBON PASTE ELECTRODE

A method for determination of paracetamol is established by the differential pulse voltammetry (DPV) using a pumice mixed carbon paste electrode with the pumice weight percent of 6% (m/m) in 0.1 mol l −1 H 2 SO 4 . The anodic peak potential is ca. 0.640 V (vs. SCE). There is a good linear relationsh...

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Bibliographic Details
Published in:Analytical letters 2001-12, Vol.34 (15), p.2747-2759
Main Authors: Wang, Chengyin, Hu, Xiaoya, Leng, Zongzhou, Yang, Gongjun, Jin, Gendi
Format: Article
Language:English
Subjects:
Adsorption
Analysis
Biological and medical sciences
Carbon paste electrode
Differential pulse voltammetry
General pharmacology
Medical sciences
Paracetamol
Pharmacology. Drug treatments
Pumice
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Summary:A method for determination of paracetamol is established by the differential pulse voltammetry (DPV) using a pumice mixed carbon paste electrode with the pumice weight percent of 6% (m/m) in 0.1 mol l −1 H 2 SO 4 . The anodic peak potential is ca. 0.640 V (vs. SCE). There is a good linear relationship between the peak current and paracetamol concentration in the range of 6.0 × 10 −8 - 1.0 × 10 −6 mol l −1 , and 2.0 × 10 −6 - 9.8 × 10 −5 mol l −1 with the detection limit of 2.0 × 10 −8 mol l −1 . Compared with the carbon paste electrode, the detection limit of this method decreases two orders of magnitude. This method is rapid, simple, accurate and highly sensitive. Satisfactory results for determination of paracetamol in pharmaceutical preparations and urine are obtained.
ISSN:0003-2719
1532-236X
DOI:10.1081/AL-100108420