DETERMINATION OF TRACE XANTHINE BY ANODIC STRIPPING VOLTAMMETRY WITH CARBON NANOTUBE MODIFIED GLASSY CARBON ELECTRODE

The electrochemistry of xanthine (Xa) was studied by CV at a glassy carbon electrode modified with carbon nanotubes. A well defined, sensitive oxidation wave of xanthine and a small reduction wave were obtained. Based on the oxidation peak, a method for determination of xanthine with semi-derivative...

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Bibliographic Details
Published in:Analytical letters 2002-01, Vol.35 (14), p.2233-2244
Main Authors: Zhao, Ge, Zang, Shuangquan, Liu, Kuaizhi, Lin, Song, Liang, Ji, Guo, Xinyong, Zhang, Zhijun
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Anodic stripping voltammetry
Biological and medical sciences
Carbon nanotubes
Chemically modified electrode
Fundamental and applied biological sciences. Psychology
Intermediary metabolites. Miscellaneous
Other biological molecules
Xanthine determination
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Summary:The electrochemistry of xanthine (Xa) was studied by CV at a glassy carbon electrode modified with carbon nanotubes. A well defined, sensitive oxidation wave of xanthine and a small reduction wave were obtained. Based on the oxidation peak, a method for determination of xanthine with semi-derivative anodic stripping voltammetry at a glassy carbon electrode modified with carbon nanotubes was investigated. The stripping peak current is proportional to the concentration of Xa over the range 2.0 × 10 −7 -2.0 × 10 −5  M with 1-min accumulation. The detection limit is 4.0 × 10 −9  mol/L with 3-min accumulation. The method has been successfully applied to the determination of xanthine in human serum.
ISSN:0003-2719
1532-236X
DOI:10.1081/AL-120016098