Electrochemical Determination of Dihydrocodeine in Pharmaceuticals

Two analytical methods for the quality control of dihydrocodeine in commercial pharmaceutical formulations have been developed and compared with reference methods: a square wave voltammetric (SWV) method and a flow injection analysis system with electrochemical detection (FIA-EC). The electrochemica...

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Bibliographic Details
Published in:Analytical letters 2003-01, Vol.36 (3), p.577-590
Main Authors: Garrido, J. M. P. J., Delerue-Matos, C., Borges, F., Macedo, T. R. A., Oliveira-Brett, A. M.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Dihydrocodeine
FIA
Flow injection analysis with electrochemical detection
General pharmacology
Medical sciences
Pharmacology. Drug treatments
Square wave voltammetry
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Summary:Two analytical methods for the quality control of dihydrocodeine in commercial pharmaceutical formulations have been developed and compared with reference methods: a square wave voltammetric (SWV) method and a flow injection analysis system with electrochemical detection (FIA-EC). The electrochemical methods proposed were successfully applied to the determination of dihydrocodeine in pharmaceutical tablets and in oral solutions. These methods do not require any pretreatment of the samples, the formulation only being dissolved in a suitable electrolyte. Validation of the methods showed it to be precise, accurate and linear over the concentration range of analysis. The automatic procedure based on a flow injection analysis manifold allows a sampling rate of 115 determinations per hour.
ISSN:0003-2719
1532-236X
DOI:10.1081/AL-120018246