Use of a Melanin-Type Polymer to Improve the Selectivity of Glucose Biosensors

This paper reports the advantages of using a melanin-type polymer to improve the selectivity of glucose biosensors based on carbon paste electrodes containing Pt and glucose oxidase (GO x ). The resulting bioelectrodes combine the high sensitivity of metallized electrodes with the selectivity given...

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Bibliographic Details
Published in:Analytical letters 2003-01, Vol.36 (7), p.1311-1323
Main Authors: Rubianes, M. D., Rivas, G. A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensors
Biotechnology
Carbon paste
Fundamental and applied biological sciences. Psychology
Glucose biosensor
Glucose oxidase
Melanic polymer
Metallized electrode
Methods. Procedures. Technologies
Platinum
Various methods and equipments
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Summary:This paper reports the advantages of using a melanin-type polymer to improve the selectivity of glucose biosensors based on carbon paste electrodes containing Pt and glucose oxidase (GO x ). The resulting bioelectrodes combine the high sensitivity of metallized electrodes with the selectivity given by the polymeric layer. They exhibit excellent performance for glucose with a rapid response (around 10 sec per sample), a wide linear range (up to 3.0 × 10 −2  M), low detection limits (60 μM) and a highly reproducible response (R.S.D. of 4.9%). The bioelectrodes are stable with prolonged use and almost free from the interference of easily oxidizable compounds found in biological fluids, such as ascorbic acid (AA), uric acid (UA) and acetaminophen.
ISSN:0003-2719
1532-236X
DOI:10.1081/AL-120021088