A Depressed Myocardium

Background: Venlafaxine is a potent neuronal serotonin and noradrenaline reuptake inhibitor, and to a lesser extent an inhibitor of dopamine reuptake. Paroxetine is a potent selective inhibitor of serotonin reuptake. Case Report: A 27-year-old man ingested 1987.5 mg of venlafaxine and 360 mg of paro...

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Bibliographic Details
Published in:Journal of toxicology. Clinical toxicology 2000, Vol.38 (4), p.453-455
Main Authors: Partridge, Samuel J., MacIver, David H., Solanki, Tarun
Format: Article
Language:English
Subjects:
Adult
Anti-Arrhythmia Agents
Biological and medical sciences
Cardiomyopathies - chemically induced
Cardiomyopathies - diagnosis
Chest Pain - chemically induced
Cyclohexanols - poisoning
Drug intoxications. Doping
Electrocardiography
Heart - drug effects
Humans
Hypertension - chemically induced
Hypertrophy, Left Ventricular - chemically induced
Male
Medical sciences
paroxetine
Paroxetine - poisoning
Pharmacology. Drug treatments
Serotonin Uptake Inhibitors - poisoning
Tachycardia, Sinus - chemically induced
venlafaxine
Venlafaxine Hydrochloride
Ventricular Function, Left - drug effects
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Summary:Background: Venlafaxine is a potent neuronal serotonin and noradrenaline reuptake inhibitor, and to a lesser extent an inhibitor of dopamine reuptake. Paroxetine is a potent selective inhibitor of serotonin reuptake. Case Report: A 27-year-old man ingested 1987.5 mg of venlafaxine and 360 mg of paroxetine. He subsequently developed systolic and diastolic hypertension, transient electrocardiographic abnormalities, and an area of persistent myocardial damage. He recovered from his overdose with his blood pressure and electrocardiogram returning to normal. The area of myocardial damage was documented on echocardiogram as an area of marked hypokinesia at the basal anterior septum. Despite the absence of confirming blood levels or the absolute exclusion of cocaine, this case indicates that venlafaxine and paroxetine have the potential for serious cardiotoxicity when taken in overdose.
ISSN:0731-3810
1097-9875
DOI:10.1081/CLT-100100957