Chlorpropamide Toxicity with Survival Despite 27-Day Hypoglycemia

Case Report: In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, r...

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Bibliographic Details
Published in:Journal of toxicology. Clinical toxicology 1999, Vol.37 (7), p.869-871
Main Authors: Ciechanowski, Kazimierz, Borowiak, Krzysztof S., Borowiak, Krzysztof, Potocka, Barbara A., Nowacka, Maria, Dutkiewicz, Grazyna
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
chlorpropamide
Chlorpropamide - poisoning
Chlorpropamide - urine
Drug intoxications. Doping
Electrocardiography
Female
Humans
Hypoglycemia - blood
Hypoglycemia - chemically induced
Hypoglycemic Agents - poisoning
Hypoglycemic Agents - urine
Medical sciences
Pharmacology. Drug treatments
Respiration, Artificial
Shock - chemically induced
Shock - physiopathology
Suicide, Attempted
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Summary:Case Report: In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, responded to intensive support including 3 days of cardiac pacing. Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. The toxic mechanisms and high risk of chlorpropamide are summarized. A fatal therapeutic dose ratio as low as 4:1 has made this antidiabetic agent obsolete.
ISSN:0731-3810
1097-9875
DOI:10.1081/CLT-100102468