Prognostic Significance of the Deleted in Colorectal Cancer Gene Protein Expression in High-Risk Resected Gastric Carcinoma: ORIGINAL ARTICLE

The deleted in colorectal cancer (DCC) gene is a candidate tumor suppressor gene that may be associated with differentiation and proliferation of normal cells. Loss of heterozygosity (LOH) of 18q, where the gene is located, and absence of DCC protein expression have been associated with worse progno...

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Bibliographic Details
Published in:Cancer investigation 2003-01, Vol.21 (3), p.333-340
Main Authors: Bamias, Aristotle T., Bai, Maria C., Agnantis, Niki J., Michael, Michael C., Alamanos, Yiannis P., Stefanaki, Stella V., Razi, Evagelia D., Skarlos, Dimosthenis V., Kappas, Angelos M., Pavlidis, Nicholas A.
Format: Article
Language:English
Subjects:
DCC
Gastric cancer
Immunohistochemistry
PCNA
Prognosis
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Summary:The deleted in colorectal cancer (DCC) gene is a candidate tumor suppressor gene that may be associated with differentiation and proliferation of normal cells. Loss of heterozygosity (LOH) of 18q, where the gene is located, and absence of DCC protein expression have been associated with worse prognosis in certain subgroups of patients with colorectal adenocarcinoma. We studied the prognostic significance of loss-of-protein expression in 66 patients with resected gastric cancer with a high probability of relapse (T3, T4, N+). The DCC protein was detected with immunohistochemistry using an anti-DCC monoclonal antibody on paraffin-embedded sections. The DCC protein expression was present in 51 cases (77.3%) and absent in 15 cases (22.7%). Poorly differentiated and signet ring carcinomas had significantly lower expression than more differentiated tumors(p
ISSN:0735-7907
1532-4192
DOI:10.1081/CNV-120018219