Determination of Methotrimeprazine in Pharmaceutical Preparations by Visible Spectrophotometry

A spectrophotometric method is described for determination of methotrimeprazine (levomepromazine). The aim of this work was to develop a simple, rapid, precise, and accurate visible spectrophotometric method for determination of methotrimeprazine in tablet, oral solution, and injection. The method i...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2000-01, Vol.26 (3), p.261-266
Main Authors: Kedor-Hackmann, E. R. M., Prado, M. S. Aurora, Santoro, M. I. R. M.
Format: Article
Language:English
Subjects:
Analysis
Antipsychotic Agents - analysis
Antipsychotic Agents - chemistry
Biological and medical sciences
Drug Compounding
General pharmacology
Humans
Medical sciences
Methotrimeprazine - analysis
Methotrimeprazine - chemistry
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Reproducibility of Results
Sensitivity and Specificity
Spectrophotometry - methods
Spectrophotometry - standards
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Summary:A spectrophotometric method is described for determination of methotrimeprazine (levomepromazine). The aim of this work was to develop a simple, rapid, precise, and accurate visible spectrophotometric method for determination of methotrimeprazine in tablet, oral solution, and injection. The method is based on methotrimeprazine reaction with bromophenol blue, resulting in a stable, light yellow-green ion-pair complex that, after extraction with chloroform, presented maximum absorption at 409 nm. Beer's law was obeyed in the concentration range from 5.0 to 25.0 μg ml. The proposed standardized method was applied to commercially available and simulated samples. The accuracy of the method was confirmed by recovery tests.
ISSN:0363-9045
1520-5762
DOI:10.1081/DDC-100100354