Nude Mice as a Model for Gonadotropin-Induced Adrenocortical Neoplasia

Certain inbred mice (e.g., DBA 2J, CE) develop sex steroid producing adrenocortical tumors following gonadectomy. This adrenal response is thought to result from an unopposed increase in circulating gonadotropins and or a decrease in factor(s) of gonadal origin. To differentiate between these two po...

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Bibliographic Details
Published in:Endocrine research 2004-01, Vol.30 (4), p.913-917
Main Authors: Bielinska, M., Genova, E., Boime, I., Parviainen, H., Kiiveri, S., Rahman, N., Leppäluoto, J., Heikinheimo, M., Wilson, D. B.
Format: Article
Language:English
Subjects:
Adrenal Cortex Neoplasms - chemically induced
Adrenal Cortex Neoplasms - metabolism
Adrenal Cortex Neoplasms - pathology
Adrenal tumor
Animals
CHO Cells - metabolism
CHO Cells - transplantation
Chorionic Gonadotropin - metabolism
Cricetinae
Cricetulus
Disease Models, Animal
Estradiol - biosynthesis
Estradiol - blood
Female
Mice
Mice, Nude
Ovariectomy
Steroidogenesis
Testosterone - blood
Transfection
Xenograft
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Summary:Certain inbred mice (e.g., DBA 2J, CE) develop sex steroid producing adrenocortical tumors following gonadectomy. This adrenal response is thought to result from an unopposed increase in circulating gonadotropins and or a decrease in factor(s) of gonadal origin. To differentiate between these two possibilities, we utilized the NU J strain of nude mice, which are immunologically compromised and therefore permissive to xenografts. One group of female nude mice was gonadectomized, while another group of females received xenografts of CHO cells stably transfected with human chorionic gonadotropin (hCG). After 1-2 months, subcapsular adrenocortical neoplasms containing sex steroid-producing cells were observed in both groups. We conclude that high levels of circulating gonadotropins are sufficient to induce adrenocortical tumorigenesis, even in the presence of intact gonads.
ISSN:0743-5800
1532-4206
DOI:10.1081/ERC-200044147