Preliminary Study of Pulsed-Electromagnetic Fields Effects on Endothelial Cells Line Secretions: Evidence of a Potential Increased Thrombotic Risk

We investigated the role of a 1 Hz low-strength magnetic pulse superimposed on the environmental electromagnetic field (emf) on the secretion of anti-aggregant (prostacyclin or PGI2) and pro-aggregant (thromboxane A2 or TXA2) agents in the EaHy-926 endothelial cell line. We established that magnetic...

Full description

Saved in:
Bibliographic Details
Published in:Electromagnetic biology and medicine 2004-01, Vol.23 (1), p.45-54
Main Authors: Caprani, Adrien, Richert, Alain, Guerbaoui, Samir, Guglielmi, Jean-Paul, Flaud, Patrice
Format: Article
Language:English
Subjects:
Environmental electromagnetic field
Magnetic pulse
Prostacyclin (PGI
Thromboxane A
TXA
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated the role of a 1 Hz low-strength magnetic pulse superimposed on the environmental electromagnetic field (emf) on the secretion of anti-aggregant (prostacyclin or PGI2) and pro-aggregant (thromboxane A2 or TXA2) agents in the EaHy-926 endothelial cell line. We established that magnetic pulse exposure has opposite effects on the two secretions: PGI2 is decreased, whereas TXA2 is increased, with a PGI2 TXA2 ratio shifted toward thrombosis. We also show that the effect of the magnetic field depends on its orientation, normal or parallel, to the cell monolayer. Finally, we show that the amplitude of the effect does not increase with the magnitude of the magnetic pulse, particularly with PGI2 secretion, which is increased as the field magnitude is decreased, suggesting a new concept for defining a threshold for health hazards.
ISSN:1536-8378
1536-8386
DOI:10.1081/JBC-120039592