RAPID AND ACCURATE SIMULTANEOUS DETERMINATION OF FOSINOPRIL SODIUM AND HYDROCHLOROTHIAZIDE IN TABLETS BY HPLC

A new, simple, precise, accurate, and rapid reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril sodium and hydrochlorothiazide from tablets. The procedure is based on the use of the RP-HPLC method with a UV detect...

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Bibliographic Details
Published in:Journal of liquid chromatography & related technologies 2001-04, Vol.24 (7), p.983-991
Main Authors: Özkan, Sibel A., Akay, Cemal, Cevheroglu, Şemsettin, Şentürk, Zühre
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacology. Drug treatments
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Summary:A new, simple, precise, accurate, and rapid reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril sodium and hydrochlorothiazide from tablets. The procedure is based on the use of the RP-HPLC method with a UV detector. Each analysis requires no longer than 6 minutes. A reversed phase C 18 column with a mobile phase composed of a mixture of methanol: water (40:60, v/v), adjusted to pH 4 with 10% orthophosphoric acid, was used to separate both compounds with sulfamethoxazole, as an internal standard, in a reasonable time period. The linearity range for fosinopril sodium and hydrochlorothiazide was 1.6-30 μg/mL and 1-30 μg/mL, respectively. The detection limits for fosinopril sodium and hydrochlorothiazide were 0.29 μg/mL and 0.26 μg/mL, respectively.
ISSN:1082-6076
1520-572X
DOI:10.1081/JLC-100103424