New Trends in Synthesis of Pyrazole Nucleosides as New Antimetabolites

Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates...

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Bibliographic Details
Published in:Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2005-07, Vol.24 (8), p.1227-1247
Main Authors: Elgemeie, Galal H., Zaghary, Wafaa A., Amin, Kamelia M., Nasr, Tamer M.
Format: Article
Language:English
Subjects:
Antimetabolites - chemical synthesis
Antimetabolites - chemistry
Antimetabolites - therapeutic use
Antiviral Agents - chemical synthesis
Antiviral Agents - chemistry
Antiviral Agents - therapeutic use
DNA Viruses
Pyrazoles - chemical synthesis
Pyrazoles - chemistry
Pyrazoles - therapeutic use
Ribonucleosides - chemical synthesis
Ribonucleosides - chemistry
Ribonucleosides - therapeutic use
Structure-Activity Relationship
Virus Diseases - drug therapy
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Summary:Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its α-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-200067421