STUDIES ON THE DIASTEREO- SELECTIVE REDUCTION OF 2-ACETYL-2-ALKYL- γ-BUTYROLACTONES WITH BORON HYDRIDES1

Reduction of 2-acetyl-2-alkyl-γ-butyrolactone derivatives with boron hydrides in the presence and absence of several chelating agents were studied. This process is influenced more by steric than chelation factors, yielding the isomeric alcohols syn (13-23) and anti (14-24) in good diastereomeric exc...

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Bibliographic Details
Published in:Synthetic communications 2002-01, Vol.32 (4), p.505-526
Main Authors: Teixeira, Lis H. P., de Souza, Maria Cecília B. V., Ramos, Maria da Conceição K. V., de Aquino Neto, Francisco R., Barreiro, Eliezer J., Fraga, Carlos A. M.
Format: Article
Language:English
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Summary:Reduction of 2-acetyl-2-alkyl-γ-butyrolactone derivatives with boron hydrides in the presence and absence of several chelating agents were studied. This process is influenced more by steric than chelation factors, yielding the isomeric alcohols syn (13-23) and anti (14-24) in good diastereomeric excess. *This paper is the contribution #53 from LASSbio.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120002396