SELECTIVE CONVERSION OF 2′,7-BIS-MONOCHLOROACETYLPACLITAXEL ANALOGS TO 7-MONOCHLOROACETYL DERIVATIVES BY SOLVOLYSIS IN METHANOL

2′,7-bis-Monochloroacetylpaclitaxel analogs can be conveniently converted to their corresponding 7-monochloroacetyl derivatives by allowing dilute methanolic solutions to stand at ambient temperature for 48 h.

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Bibliographic Details
Published in:Synthetic communications 2002-01, Vol.32 (17), p.2711-2718
Main Authors: Klis, Wieslaw A., Sarver, Jeffrey G., Erhardt, Paul W.
Format: Article
Language:English
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Description
Summary:2′,7-bis-Monochloroacetylpaclitaxel analogs can be conveniently converted to their corresponding 7-monochloroacetyl derivatives by allowing dilute methanolic solutions to stand at ambient temperature for 48 h.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120006037