A Convenient Procedure for the Synthesis of O6-Benzylguanine Derivatives by Phase Transfer Catalysis

A convenient procedure by phase transfer catalysis has been developed for the synthesis of O 6 -BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG (3a-c, 4a-c, 5a-c, 6a-c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c, 5b, 5c, 6a, and 6c are new compounds.

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Bibliographic Details
Published in:Synthetic communications 2003-01, Vol.33 (6), p.941-952
Main Authors: Liu, Xuan, Zheng, Qi-Huang, Hutchins, Gary D., Fei, Xiangshu, Erickson, Leonard C., Miller, Kathy D., Mock, Bruce H., Glick-Wilson, Barbara E., Winkle, Wendy L., Lee Stone, K., Carlson, Kathy A.
Format: Article
Language:eng ; jpn
Subjects:
Alkylguanine-DNA alkyltransferase
Benzylguanine derivatives
Phase transfer catalysis
Synthesis
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Summary:A convenient procedure by phase transfer catalysis has been developed for the synthesis of O 6 -BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG (3a-c, 4a-c, 5a-c, 6a-c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c, 5b, 5c, 6a, and 6c are new compounds.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120016358